Investigating the Effects of Acoustic Therapy on the Nasal Microbiome and Well-being

Authors

  • Jude Alao School of Public Health and Interdisciplinary Studies, Auckland University of Technology, Auckland, New Zealand
  • Kelvin Lau School of Public Health and Interdisciplinary Studies, Auckland University of Technology, Auckland, New Zealand
  • David White BioDesign Research Hub, New Zealand College of Chiropractic
  • Kevin Lee School of Science, Auckland University of Technology, Auckland, New Zealand
  • Chris Puli'uvea School of Science, Auckland University of Technology, Auckland, New Zealand
  • Jim Bartley Department of Surgery, University of Auckland, Auckland, New Zealand

DOI:

https://doi.org/10.24135/rangahau-aranga.v3i2.233

Abstract

This study aims to investigate the effects of acoustic therapy on the nasal microbiome, immune responses, and overall well-being in patients with allergic rhinitis (AR) and chronic rhinosinusitis (CRS). Utilizing the Goodair® NoseBuds, a low-cost acoustic device developed by the AUT BioDesign Lab, this research explores the potential of nasal mechanostimulation to increase endogenous nitric oxide production, improve nasal health, and alleviate AR and CRS symptoms. Participants will use the device twice daily over a four-week period, and the study will assess changes in nasal microbiome composition, inflammation markers, and patient-reported outcomes, such as symptom severity and quality of life. Data will be analysed through bioinformatics and statistical methods to identify correlations between acoustic therapy and immune or microbial changes. This research offers an innovative, non-pharmaceutical alternative for managing AR and CRS, with the potential to reduce reliance on traditional medications and improve patient outcomes.

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References

Behnke, J., Dundervill, C., Bulbul, M., Armeni, M., Ramadan, H. H., & Makary, C. A. (2023). Using the sino-nasal outcome test (SNOT-22) to study outcome of treatment of nasal obstruction. American Journal of Otolaryngology, 44(4), 103879. https://doi.org/10.1016/j.amjoto.2023.103879

Gokani, S. A., Espehana, A., Pratas, A. C., Luke, L., Sharma, E., Mattock, J., Gavrilovic, J., Clark, A., Wileman, T., & Philpott, C. M. (2023). Systematic Review of Protein Biomarkers in Adult Patients With Chronic Rhinosinusitis. American Journal of Rhinology & Allergy, 37(6), 705–729. https://doi.org/10.1177/19458924231190568

Wang, J., Zhou, Y., Zhang, H., Hu, L., Liu, J., Wang, L., Wang, T., Zhang, H., Cong, L., & Wang, Q. (2023). Pathogenesis of allergic diseases and implications for therapeutic interventions. Signal Transduction and Targeted Therapy, 8(1), 138. https://doi.org/10.1038/s41392-023-01344-4

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Published

2025-01-28

How to Cite

Alao, J., Lau, K. ., White, D. ., Lee, K., Puli’uvea, C. ., & Bartley, J. . (2025). Investigating the Effects of Acoustic Therapy on the Nasal Microbiome and Well-being. Rangahau Aranga: AUT Graduate Review, 3(1). https://doi.org/10.24135/rangahau-aranga.v3i2.233

Issue

Vol. 3 No. 1 (2025): Methodology Special Issue

Section

Research Methodologies Issue

License

Copyright (c) 2024 Jude Alao, Kelvin Lau, David White, Kevin Lee, Chris Puli'uvea, Jim Bartley

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.